O-102 Add-ons in the ART clinic

Abstract Study question Which add-ons are effective and safe to use in the ART clinic? Summary answer More than thirty recommendations were formulated on of diagnosis diagnostic tests, laboratory tests intervention, clinical management. What is known already Treatment not essential for treatment but optional additional treatments that sometimes offered top routine fertility treatment. There a wide range offer including drugs, equipment, holistic or alternative therapies, surgical interventions, consistently, they aim potentiate effect lessen side effects herein improve pregnancy live birth rate, reduce risk miscarriage shorten time pregnancy. Evidence whether some often missing absent. Add-ons can be proven evidence-based (or not) at extra cost not), presumable both beneficial non-beneficial, as there may absence evidence either. design, size, duration The ESHRE working group good practice has produced useful professionals, patients policy makers identified more 30 evaluated each one them efficiency safety wherever possible also costs. literature was systematic search, reviewed critically appraised. In any clear scientific evidence, judgement based professional experience consensus development group. guidelines thus best available expert agreement. Prior publication, by independent international reviewers. Participants/materials, setting, methods Interventions characterized three sections: 1) Diagnosis 2) Laboratory 3) Clinical Outcomes efficacy (pregnancy rate), miscarriage, pregnancy, costs, safety/risk aspects. This lecture will focus relevant clinic endometrial receptivity assisted hatching, freeze-all (elective), ICSI uterine flushing scratching. Main results role chance multidisciplinary recommendations. provides summary currently used clinics. First it described how an add-on hypothesized have IVF treatment, its efficacy, safety. While most recommended general population patients, indications where specific patient populations might benefit. guideline been stakeholder review prepared submission 2023. Limitations, reason caution Of recommendations, none high quality only few moderate evidence. Hence 90% supported low RCTs, observational data, experience, Wider implications findings These provide guidance health care professionals experts field reproductive medicine, help towards efficient participate informed decision making with realistic expectations fully about their changes birth. funding competing interest(s) All costs relating process covered from funds. no external manuscript production. authors stated conflicts interest if any.